Paul Harmatz Selected Research

Iron Overload

2/2015	Pulmonary hypertension in well-transfused thalassemia major patients.
2/2013	Combined chelation therapy with deferasirox and deferoxamine in thalassemia.
4/2012	A phase 2 study of the safety, tolerability, and pharmacodynamics of FBS0701, a novel oral iron chelator, in transfusional iron overload.
2/2012	Electrocardiographic consequences of cardiac iron overload in thalassemia major.
4/2011	A phase 1 dose-escalation study: safety, tolerability, and pharmacokinetics of FBS0701, a novel oral iron chelator for the treatment of transfusional iron overload.
10/2010	Management of chronic viral hepatitis in patients with thalassemia: recommendations from an international panel.
2/2008	Transfusional iron burden and liver toxicity after bone marrow transplantation for acute myelogenous leukemia and hemoglobinopathies.
9/2007	Serum ferritin underestimates liver iron concentration in transfusion independent thalassemia patients as compared to regularly transfused thalassemia and sickle cell patients.
6/2007	Iron homeostasis during transfusional iron overload in beta-thalassemia and sickle cell disease: changes in iron regulatory protein, hepcidin, and ferritin expression.
4/2007	Morbidity and mortality in chronically transfused subjects with thalassemia and sickle cell disease: A report from the multi-center study of iron overload.

For more, sign up at right for free...

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!

Paul Harmatz Research Topics

Disease

26	Mucopolysaccharidoses 09/2023 - 02/2008
17	Mucopolysaccharidosis VI (Syndrome, Maroteaux-Lamy) 01/2021 - 05/2004
14	Iron Overload 02/2015 - 11/2004
13	beta-Thalassemia (Cooley's Anemia) 03/2013 - 01/2005
12	Thalassemia 02/2013 - 01/2005
11	Mucopolysaccharidosis II (Hunter Syndrome) 11/2023 - 08/2006
10	Lysosomal Storage Diseases (Lysosomal Storage Disease) 01/2023 - 04/2005
8	Sickle Cell Anemia (Hemoglobin S Disease) 08/2009 - 01/2005
7	Disease Progression 11/2021 - 04/2005
6	Mucopolysaccharidosis I (Hurler Syndrome) 01/2024 - 12/2013
6	Achondroplasia 01/2024 - 01/2019
6	Mucopolysaccharidosis IV (Morquio Syndrome) 06/2022 - 01/2013
6	Inflammation (Inflammations) 03/2013 - 10/2006
5	Cognitive Dysfunction 01/2023 - 01/2012
5	Hemoglobinopathies 03/2010 - 01/2005
4	Mucopolysaccharidosis VII (Sly Syndrome) 09/2020 - 01/2018
4	Hemolysis 02/2015 - 01/2005
3	Glycogen Storage Disease Type II (Pompe's Disease) 12/2022 - 01/2013
3	Spinal Cord Compression 01/2020 - 01/2013
3	Hepatitis 10/2010 - 09/2005
3	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 02/2009 - 02/2007
2	Medically Unexplained Symptoms 01/2024 - 09/2022
2	Mucopolysaccharidosis III (Sanfilippo Syndrome) 01/2022 - 01/2018
2	Rare Diseases (Rare Disease) 10/2021 - 01/2020
2	Sleep Wake Disorders 01/2019 - 01/2019
2	Body Weight (Weight, Body) 01/2019 - 04/2005
2	Hypophosphatasia 01/2019 - 01/2017
2	alpha-Mannosidosis 11/2018 - 01/2018
2	Pain (Aches) 01/2017 - 10/2015
2	Gaucher Disease (Gaucher's Disease) 02/2016 - 03/2013
2	Anemia 02/2015 - 06/2007
2	Siderosis 01/2014 - 10/2010
2	Multiple Sulfatase Deficiency Disease (Mucosulfatidosis) 03/2013 - 04/2010
2	Cardiomyopathies (Cardiomyopathy) 02/2012 - 01/2009
2	Phenylketonurias (Phenylketonuria) 05/2009 - 01/2008
2	Neoplasms (Cancer) 02/2009 - 02/2007
2	Ulcerative Colitis 02/2009 - 02/2007
2	Crohn Disease (Crohn's Disease) 02/2009 - 03/2008
2	Obesity 01/2009 - 08/2008
2	Cardiovascular Diseases (Cardiovascular Disease) 01/2009 - 08/2008
2	Hemosiderosis 09/2005 - 01/2005
1	Injection Site Reaction 01/2024
1	Bronchiolitis 01/2024
1	Otitis Media 01/2024
1	Gastroenteritis 01/2024
1	Sudden Infant Death (SID) 01/2024
1	Vomiting 01/2024
1	Erythema 01/2024
1	Pneumonia (Pneumonitis) 01/2024
1	Paramyxoviridae Infections (Parainfluenza) 01/2024
1	Absence Epilepsy (Childhood Absence Epilepsy) 01/2024
1	Skull Fractures (Skull Fracture) 01/2024

Drug/Important Bio-Agent (IBA)

28	IronIBA 02/2015 - 11/2004
20	EnzymesIBA 01/2024 - 06/2005
14	N-Acetylgalactosamine-4-Sulfatase (Arylsulfatase B)IBA 01/2019 - 05/2004
12	GlycosaminoglycansIBA 01/2024 - 04/2005
10	idursulfase FDA Link 11/2023 - 08/2006
6	human GALNS proteinIBA 01/2017 - 11/2014
6	Deferoxamine (Desferal)FDA LinkGeneric 02/2013 - 01/2005
5	vosoritideIBA 01/2024 - 01/2019
5	Deferasirox FDA Link 02/2013 - 01/2005
4	Iduronidase (alpha-L-Iduronidase)IBA 01/2024 - 12/2013
4	galsulfase FDA Link 01/2021 - 08/2009
4	vestronidase alfaIBA 09/2020 - 01/2018
4	Biomarkers (Surrogate Marker)IBA 01/2018 - 10/2006
4	Chelating AgentsIBA 04/2012 - 01/2005
4	Ferritins (Ferritin)IBA 02/2008 - 04/2007
3	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2024 - 01/2019
3	Keratan SulfateIBA 06/2022 - 09/2015
3	SulfatasesIBA 02/2016 - 04/2010
2	Heparitin Sulfate (Heparan Sulfate)IBA 01/2023 - 01/2022
2	RNA (Ribonucleic Acid)IBA 06/2022 - 06/2007
2	Type 3 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 3)IBA 01/2022 - 12/2021
2	GlucuronidaseIBA 01/2020 - 09/2019
2	N- (4'- fluorobutyrophenone)- 4- (4- chlorophenyl)pyridinium (HPP(+))IBA 01/2019 - 01/2017
2	asfotase alfaIBA 01/2019 - 01/2017
2	alpha-Mannosidase (LAMAN)IBA 11/2018 - 01/2018
2	AntibodiesIBA 01/2017 - 09/2015
2	imiglucerase FDA Link 02/2016 - 03/2013
2	Proteins (Proteins, Gene)FDA Link 09/2015 - 01/2008
2	Hemoglobins (Hemoglobin)IBA 02/2015 - 03/2010
2	4,5- dihydro- 2- (2- hydroxy- 3- (3,6,9- trioxadecyloxy)phenyl)- 4- methyl- 4- thiazolecarboxylic acidIBA 04/2012 - 04/2011
2	DeferiproneIBA 10/2011 - 01/2005
2	Isoflurophate (DFP)FDA Link 10/2011 - 01/2005
2	Antiviral Agents (Antivirals)IBA 10/2010 - 08/2008
2	Dermatan SulfateIBA 04/2010 - 08/2009
2	CreatinineIBA 04/2010 - 04/2005
2	HepcidinsIBA 08/2009 - 06/2007
2	CytokinesIBA 08/2009 - 03/2008
2	Phenylalanine (L-Phenylalanine)FDA Link 05/2009 - 01/2008
2	sapropterin (tetrahydrobiopterin)FDA Link 05/2009 - 01/2008
2	Folic Acid (Vitamin M)FDA LinkGeneric 02/2009 - 02/2007
2	Ribavirin (Virazole)FDA LinkGeneric 08/2008 - 01/2005
2	Interferon-alpha (Interferon Alfa)IBA 08/2008 - 01/2005
1	Transferrin Receptors (Transferrin Receptor)IBA 01/2024

Therapy/Procedure

35	Enzyme Replacement Therapy 01/2024 - 05/2004
22	Therapeutics 01/2024 - 01/2005
4	Chelation Therapy (Therapy, Chelation) 02/2013 - 01/2005
4	Blood Transfusion (Blood Transfusions) 04/2010 - 01/2005
2	Hematopoietic Stem Cell Transplantation 01/2020 - 01/2019